Question 1

Which of the following statements is true regarding Drug-receptor bonds?

Options :

A : Covalent bonds of drugs with receptors are strong and mostly reversible

B : Covalent bonding is much more common than electrostatic bonding in drug-receptor interactions

C : Electrostatic bonds are stronger than covalent bonds

D : Hydrophobic bonds are weak bonds and they are important in the interactions of highly water soluble drugs with the lipids of cell membranes

E : Bond formation of between the acetyl group of aspirin and cyclo-oxygenase enzyme is a covalent bond

Answer: A

Question 2

Injectable Sulfamethoxazole/Trimethoprim comes as 400mg/80mg/5ml. Physician requests you to dose a

Sulfamethoxazole/Trimethoprim intravenously for PCP. You know the dose is 15mg/kg/day (based on TMP

component) divided q6h.

How many milliliters of Sulfamethoxazole/Trimethoprim of 400mg/80mg/5ml would you need for single

dose? Patient weighs 80kg.

Options :

A : 18.75 mL

B : 75 mL

C : 15 mL

D : 50 mL

E : 16.5 mL

Answer: A

Question 3

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches, weight 85 kg and

NKDA.

His past medical history includes hypertension, diabetes mellitus, major depression, hypothyroidism and

chronic back pain. Post-op day 1, LN’s medication includes Dexamethasone 8mg iv q6h with taper dosing,

Ondansetron 4mg iv q6h prn for N/V, Levothyroxine 0.075mg po daily, Lisinopril 10mg po daily, Citalopram

20mg po daily, Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10mg suppository daily prn for

constipation, Famotidine 20 mg iv q12hr, Metoclopramide 10mg iv q6h, Metformin 500mg po bid, D51/2NS

with 20K at 125 mls/hour and Hydromorphone PCA at 0.2 mg/hour of basal rate, demand dose 0.1mg. lockout every 6min, one hour limit 2.2mg/hour. Pertinent morning labs includes serum creatinine 1.4mg/dl, Mg

1.5mg/dl, K 5.0mmol/L, Na 135mmol/L. Day 3 post-operation LN’s pain was much better and only used 3

mg of hydromorphone in the 24hrs.

Physician wants to change to oral morphine. What would be your best recommendation?

Options :

A : Morphine SR 10mg po daily and morphine 5mg po q6h prn for breakthrough pain

B : Morphine 60mg ER po daily and morphine 15mg po q6h prn breakthrough pain

C : Morphine 30mg ER po q6hr and morphine 5mg q6h prn for breakthrough pain

D : Morphine 15mg ER po q12hr and morphine 15mg po q6h prn for breakthrough pain

E : Morphine 15mg ER po q12hr and morphine 5mg po q6h prn breakthrough pain

Answer: A

Question 4

Which of the following NSAIDs is an Enolic acid derivative?

Options :

A : Ibuprofen

B : Piroxicam

C : Naproxen

D : Oxaprozin

E : Fenoprofen

Answer: B

Question 5

Which of the following Anti-epileptic medication can cause pancreatitis?

Options :

A : Carbamazepine

B : Gabapentin

C : Valproic acid

D : Levetiracetam

E : Phenobarbital

Answer: C